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Colombia has a unique patient population for studying Alzheimer’s disease.

University of Antioquia in studying the largest known family with inherited Alzheimer’s disease. Its family tree goes back 300 hundred years. Symptoms in this family typically develop between the ages of 45 and 50.

The gene, called presenilin 1 (PSEN1), that is responsible for this family’s disease. Knowing the gene means we can predict which individuals will get Alzheimer’s.

Most people with PSEN1 variant develop Alzheimer’s disease before age 50, a few develop it later. These individuals carry a genetic variant that provides some protection against the disease. This gene can delay Alzheimer’s onset by as much eight to 10 years