Latin American (LA) countries operate increasingly in accordance with international standards and guidelines. This has been a major driver for increasing interest and placement of clinical studies in the region. Even though LA countries are considered to have many similarities, it is important to keep in mind that, in reality, they are 20 different countries, with different cultures, regulatory requirements, pathologies, incidence rates, standards of care, etc. For this reason, it is fundamental to have local knowledge to accommodate diversity while leveraging shared characteristics. This paper will provide a quick overview of LAΓÇÖs current clinical research environment, summarize its challenges and opportunities, vis-├á-vis successful stories of other countries out of LA, in the competitive scenario of global clinical trial placement.